The main business area in Upton was the shopping area in The Village, part of Ford Road, there were also a few shops on Greasby Road and Rake Lane.

There have been other businesses in Upton, for example, there was a small engineering works in Salacre Lane and there were shops on Greasby Road

When the first by-pass (Arrowepark Road) was built in 1938, additional shops were built along one side of this, these shops were extended in the 1960s.

A second small shopping area grew up at the bottom of Saughall Massie Road, and with the building of the new estates, small blocks of shops were included at the end of Manor Drive and in the council estate at Overchurch.

In more recent times, a small trading estate has been built on 'Upton Meadow', this includes branches of Sainsbury's,  Homebase,  Argos and a drive through MacDonalds.